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ISSN: 2377-6196
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Research Article

Anti-diabetic activity of Physagulin-F isolated from Physalis angulata fruits

Sateesh Pujari1* and Estari Mamidala2

1,2 Metabolic Disorders & Infectious Diseases Research Lab, Kakatiya University, Warangal-506 009. Telangana State, India


Abstract
Type 2 diabetes is a chronic medical condition that requires regular monitoring and treatment throughout your life. Natural compounds from plant sources have been extensively used as traditional medicines from centuries.  The present study was carried out to isolate and identify the putative antidiabetic compound from the Physalis angulata (PA) fruit. A compound, Physagulin-F was isolated from PA fruit extract. The isolated compound Physagulin-F (100, 300 and 500 mg/kg) of Physalis angulata fruit was undertaken to evaluate the anti-diabetic activity against streptozotocin (STZ)-induced diabetic rates. The compound ‘Physagulin-F’ produced significant
(p<0.5) reduction in blood glucose level. The standard drug, glibenclamide (1.25 mg/kg) also produced significant (p<0.05) reduction in blood glucose level against STZ-induced diabetic rats. The results of this experimental study indicate that isolated compound ‘Physagulin-F’, possess anti-diabetic effects against STZ-induced diabetic rats.

Keywords: Physalis angulata, Physagulin-F, anti-diabetic, Type 2 diabetes

Published online 20th April, 2015
© 2015 Published by Global Science Publishing Group, USA

Cite this Article as
Sateesh Pujari and Estari Mamidala (2015). Anti-diabetic activity of Physagulin-F isolated from Physalis angulata fruits. The Ame J Sci & Med Res, 2015,1(1):53-60. doi:10.17812/ajsmr2015113
The Ame J Scie & Med Res, Volume 1, Issue 1
DOI: http://dx.doi.org/10.17812/ajsmr2015113
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