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Research Article

Metabolic effects of protease inhibitors in human immunodeficiency virus (HIV) infected patients

T. Shivalingu


Govt. Mandal Parisad Primary School, Savapur, MP: Jainad, Adilabad district-504001, Telangana State, India

E-mail:
tshivalingu.adb@gmail.com

Abstract
The present study focuses on the prevalence and characteristics of the metabolic syndrome in HIV-infected patients and possible related factors, including individual antiretroviral drug exposure. A cross-sectional study was carried out on 720 HIV-infected patients managed at the outpatient Infectious Disease Unit of the Mahatma Gandhi Memorial Hospital, Warangal, Andhra Pradesh, over a period of 1 year, from September through August 2007.  Age, sex, HIV disease status according to Disease Control and Prevention (CDC) classification of HIV disease, HIV exposure (mutually exclusive in the following order: intravenous drug use, male homosexual activity, heterosexual activity), and type and duration of ART were recorded. The results shows that one or more features of metabolic syndrome were seen in 492 (69.3%) patients, two or more in 254 (35.8%), three or more in 121 (17%) and four or more in 32 (4.5%), and five features were seen in 1 patient (0.1%). Thus, 121 patients (86 men, 35 women) metabolic syndrome criteria, yielding a prevalence of 69.2% (492/710). This was significantly increased in age 31-40 years of HIV infected patients. A total of 116 patients were on combination ART, and 5 were naive HIV-infected patients. This study concludes that, a significant positive correlation was observed between the level of neutropenia and anemia in HIV infected subjects. It is hoped that ongoing research into the molecular mechanisms of insulin resistance and lipodystrophy in the context of HIV infection and antiretroviral therapy will ultimately provide viable treatment options for patients with metabolic syndrome.

Key words
: Protease inhibitors, HIV, ART, Metabolic syndrome, Adilabad

Published online 18th May, 2015
2015 Published by
Global Science Publishing Group, USA

Cite this Article as

T. Shivalingu (2015). Metabolic effects of protease inhibitors in human immunodeficiency virus (HIV) infected patients. The Ame J Sci & Med Res, 1(1):101-107. doi:10.17812/ajsmr2015118
The Ame J Scie & Med Res, Volume 1, Issue 1
DOI: http://dx.doi.org/10.17812/ajsmr2015118
Article Options
10.17812_ajsmr2015117